Sohal Lab logo

Decoding communication between tumors and their environment to find better therapies

Preprint publications

Sohal IS, Shaw S, Santos AD, Elzey BD, Harper HA, McMahan C, Meeks LN, Hasan H, Soto-Vargas Z, Abdullah N, Sahoo SS, Kazemian M, Olson MR, Kasinski AL*. “Exosome-like biogenesis from the Golgi releases extracellular vesicles lacking conventional tetraspanins that mediate immune evasion in cancer.” bioRxiv (2026). https://doi.org/10.64898/2026.05.13.719612

Sohal IS*, Pal AK, Lepine J, Liu P, Wisnewski AV, Redlich CA, Bello D*. “A cross-week analysis of urinary extracellular vesicles after respiratory tract exposure intervention identifies systemic signaling changes – a pilot study of isocyanate-exposed workers.” bioRxiv (2025). https://doi.org/10.1101/2025.02.21.639517


Peer-reviewed publications

2025

Iyer SG, Sohal IS, and Kasinski AL*. “Redesigning miR-34a: structural and chemical advances in the therapeutic development of an miRNA anti-cancer agent.” Biochemical Society Transactions (2025). https://doi.org/10.1042/BST20253010

2024

Abdelaal AM, Sohal IS*, Iyer SG, Sudarshan K, Orellana EA, Ozcan K, Santos AP, Low P, and Kasinski AL*. “Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent.” Molecular Therapy – Nucleic Acids (2024). https://doi.org/10.1016/j.omtn.2024.102193

2023

Abdelaal A, Sohal IS*, Iyer S, Kasireddy S, Lanman N, Kothandaraman H, Low P, and Kasinski A*. “A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy.” Oncogene (2023). https://doi.org/10.1038/s41388-023-02801-8

Sohal IS, Kasinski, A*. “Emerging diversity in extracellular vesicles and their roles in cancer”. Frontiers in Oncology (2023). https://doi.org/10.3389/fonc.2023.1167717

Dar MS, Mensah IK, He M, McGovern S, Sohal IS, Whitlock HC, Bippus NE, Ceminsky M, Emerson ML, Tan HJ, Hall MC, Gowher H*. “Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression.” Cell Reports (2023). https://doi.org/10.1016/j.celrep.2023.112587

2022

Kaur J, Sohal IS, Singh H, Gupta NK, Sehrawat S, Puri S, Bello D*, Khatri M*. “Toxicity screening and ranking of diverse engineered nanomaterials using hierarchical testing approaches with an in vivo zebrafish model.” Environmental Science: Nano (2022). https://doi.org/10.1039/D2EN00265E

Hasan H, Sohal IS, Soto-Vargas Z, Byappanahalli, AM, Humphrey SE, Kubo H, Kitdumrongthum S, Copeland S, Tian F, Chairoungdua A, Kasinski AL*. “Extracellular vesicles released by non-small cell lung cancer cells drive invasion and permeability in non-tumorigenic lung epithelial cells.” Scientific Reports (2022). https://doi.org/10.1038/s41598-022-04940-6

Pal AS, Agredo A, Lanman NA, Son J, Sohal IS, Bains M, Li C, Clingerman J, Gates K, Kasinski AL*. “Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET.” Cancer Research (2022). https://doi.org/10.1158/0008-5472.CAN-20-0821


Earlier publications

Sohal IS, DeLoid GM, O’Fallon KS, Gaines P, Demokritou P*, Bello D*. “Effects of ingested food-grade titanium dioxide, silicon dioxide, iron (III) oxide and zinc oxide nanoparticles on an in vitro model of intestinal epithelium: Comparison between monoculture vs. a mucus-secreting coculture model.” NanoImpact (2020). https://doi.org/10.1016/j.impact.2020.100209

Liu X, Zhang B, Sohal IS, Bello D, Chen H. “Is,“nano safe to eat or not”? a review of the state-of-the art in soft engineered nanoparticle (sENP) formulation and delivery in foods.” Advances in Food and Nutrition Research (2019). https://doi.org/10.1016/bs.afnr.2019.03.004

Sohal IS†*, O’Fallon KS, Gaines P, Demokritou P, Bello D*. “Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs.” Particle and Fibre Toxicology (2018). https://doi.org/10.1186/s12989-018-0265-1

Sohal IS†*, Cho YK, O’Fallon KS, Gaines P, Demokritou P, Bello D*. “Dissolution Behavior and Biodurability of Ingested Engineered Nanomaterials in the Gastrointestinal Environment.” ACS Nano (2018). https://doi.org/10.1021/acsnano.8b02978

DeLoid GM, Sohal IS, Lorente LR, Molina RM, Pyrgiotakis G, Stevanovic A, Zhang R, McClements DJ, Geitner NK, Bousfield DW, Ng KW, Loo SCJ, Bell DC, Brain J, Demokritou P*. “Reducing Intestinal Digestion and Absorption of Fat Using a Nature-Derived Biopolymer: Interference of Triglyceride Hydrolysis by Nanocellulose.” ACS Nano (2018). https://doi.org/10.1021/acsnano.8b03074

Lee S, Sohal IS, Therrien MA, Pal AK, Bello D, Shea TB*. “Additive impairment of synaptic signaling in cultured cortical neurons by exogenously-applied oligomerized amyloid-β and airborne nanoparticles generated during photocopying.” Journal of Alzheimer’s Disease (2015). https://doi.org/10.3233/jad-150099