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Decoding communication between tumors and their environment to find better therapies

Preprint publications

Sohal IS*, Pal AK, Lepine J, Liu P, Wisnewski AV, Redlich CA, Bello D*. “A cross-week analysis of urinary extracellular vesicles after respiratory tract exposure intervention identifies systemic signaling changes – a pilot study of isocyanate-exposed workers.” bioRxiv (2025). https://doi.org/10.1101/2025.02.21.639517


Peer-reviewed publications

2025

Iyer SG, Sohal IS, and Kasinski AL*. “Redesigning miR-34a: structural and chemical advances in the therapeutic development of an miRNA anti-cancer agent.” Biochemical Society Transactions (2025). https://doi.org/10.1042/BST20253010

2024

Abdelaal AM, Sohal IS*, Iyer SG, Sudarshan K, Orellana EA, Ozcan K, Santos AP, Low P, and Kasinski AL*. “Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent.” Molecular Therapy – Nucleic Acids (2024). https://doi.org/10.1016/j.omtn.2024.102193

2023

Abdelaal A, Sohal IS*, Iyer S, Kasireddy S, Lanman N, Kothandaraman H, Low P, and Kasinski A*. “A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy.” Oncogene (2023). https://doi.org/10.1038/s41388-023-02801-8

Sohal IS, Kasinski, A*. “Emerging diversity in extracellular vesicles and their roles in cancer”. Frontiers in Oncology (2023). https://doi.org/10.3389/fonc.2023.1167717

Dar MS, Mensah IK, He M, McGovern S, Sohal IS, Whitlock HC, Bippus NE, Ceminsky M, Emerson ML, Tan HJ, Hall MC, Gowher H*. “Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression.” Cell Reports (2023). https://doi.org/10.1016/j.celrep.2023.112587

2022

Kaur J, Sohal IS, Singh H, Gupta NK, Sehrawat S, Puri S, Bello D*, Khatri M*. “Toxicity screening and ranking of diverse engineered nanomaterials using hierarchical testing approaches with an in vivo zebrafish model.” Environmental Science: Nano (2022). https://doi.org/10.1039/D2EN00265E

Hasan H, Sohal IS, Soto-Vargas Z, Byappanahalli, AM, Humphrey SE, Kubo H, Kitdumrongthum S, Copeland S, Tian F, Chairoungdua A, Kasinski AL*. “Extracellular vesicles released by non-small cell lung cancer cells drive invasion and permeability in non-tumorigenic lung epithelial cells.” Scientific Reports (2022). https://doi.org/10.1038/s41598-022-04940-6

Pal AS, Agredo A, Lanman NA, Son J, Sohal IS, Bains M, Li C, Clingerman J, Gates K, Kasinski AL*. “Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET.” Cancer Research (2022). https://doi.org/10.1158/0008-5472.CAN-20-0821


Earlier publications

Sohal IS, DeLoid GM, O’Fallon KS, Gaines P, Demokritou P*, Bello D*. “Effects of ingested food-grade titanium dioxide, silicon dioxide, iron (III) oxide and zinc oxide nanoparticles on an in vitro model of intestinal epithelium: Comparison between monoculture vs. a mucus-secreting coculture model.” NanoImpact (2020). https://doi.org/10.1016/j.impact.2020.100209

Liu X, Zhang B, Sohal IS, Bello D, Chen H. “Is,“nano safe to eat or not”? a review of the state-of-the art in soft engineered nanoparticle (sENP) formulation and delivery in foods.” Advances in Food and Nutrition Research (2019). https://doi.org/10.1016/bs.afnr.2019.03.004

Sohal IS†*, O’Fallon KS, Gaines P, Demokritou P, Bello D*. “Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs.” Particle and Fibre Toxicology (2018). https://doi.org/10.1186/s12989-018-0265-1

Sohal IS†*, Cho YK, O’Fallon KS, Gaines P, Demokritou P, Bello D*. “Dissolution Behavior and Biodurability of Ingested Engineered Nanomaterials in the Gastrointestinal Environment.” ACS Nano (2018). https://doi.org/10.1021/acsnano.8b02978

DeLoid GM, Sohal IS, Lorente LR, Molina RM, Pyrgiotakis G, Stevanovic A, Zhang R, McClements DJ, Geitner NK, Bousfield DW, Ng KW, Loo SCJ, Bell DC, Brain J, Demokritou P*. “Reducing Intestinal Digestion and Absorption of Fat Using a Nature-Derived Biopolymer: Interference of Triglyceride Hydrolysis by Nanocellulose.” ACS Nano (2018). https://doi.org/10.1021/acsnano.8b03074

Lee S, Sohal IS, Therrien MA, Pal AK, Bello D, Shea TB*. “Additive impairment of synaptic signaling in cultured cortical neurons by exogenously-applied oligomerized amyloid-β and airborne nanoparticles generated during photocopying.” Journal of Alzheimer’s Disease (2015). https://doi.org/10.3233/jad-150099